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The novel peptide is biased towards GLP-1R agonism versus GCGR with a 3-4 fold reduced potency at the GLP-1R compared to native GLP-1 and around an 8-fold reduced potency at the GCGR compared to native glucagon

Wettergren A, Schjoldager B, Mortensen PE, Myhre J, Christiansen J, Holst JJ

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May 1, 2026: GLP-1 Litigation Cases Increase As Studies Examine Other Possible Ozempic Side Effects As of May 1, 2026, there are a total of 3,636 lawsuits that have been filed or transferred into the consolidated MDL against companies that make Ozempic and other GLP-1s

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If you are planning pregnancy, discuss timing with both providersyou may need to pause GLP-1 treatment and optimize metabolic health beforehand