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Radiolabeled receptor binding assays show oxyntomodulin binds to the GLP-1R with an approximate 10-fold reduction in potency relative to native GLP-1, with a comparative 100-fold reduction in cAMP potency, indicating the extent of oxyntomodulins 8 amino acid C-terminal extension in conferring additional promiscuity at the GLP-1R [41]

(2025) 135:e186426

Retrieved from Prasadi, V

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[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF

Even if you experience short-term improvement following one or more of these magic-bullet regimens, you will eventually find that they are not sustainable in the long run