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Interestingly, chronic chemo-genetic stimulation of POA LepR-expressing neurons decreases both food intake and energy expenditure, and results in body weight loss, indicating that the reduced food intake surpasses the decreased energy expenditure [28]

Prescribers longstanding preferences for established injectables, along with the commonly held view that injections are more effective, can also shape adoption

It reduces their pleasure in eating, and it makes it harder for them to go out and socialise, which are not good things if you dont actually deal with the psychological reasons someone might be overeating in the first place

Once fundamentals are solid, these approaches offer additional tools for stubborn plateaus

This may include people with severe kidney impairment or metabolic acidosis

JL: methodology, formal analysis, and writingoriginal draft preparation