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However, in vitro and in vivo studies have demonstrated that its metabolite, GLP-1(936), reduces glucose production alone or induced by positive allosteric modulators (Elahi et al., 2008

Quartey noted that this side effect is not unique to GLP-1 receptor agonists and can occur when the drugs or other types of drugs are absorbed and released into the saliva, thereby altering the sense of taste

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Novo Nordisk noted it didnt sponsor this study and hasnt had the opportunity to evaluate the data, but said we support research for potential advancements of treatments for patients with Type 1 diabetes as well as other serious chronic conditions. The company isnt pursuing trials of semaglutide for type 1 diabetes itself, but we do continue to support investigator initiated studies, a spokeswoman told CNN by email

Orforglipron is an experimental oral GLP-1 receptor agonist developed by Eli Lilly, aimed at managing obesity and type 2 diabetes