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This was quickly followed by Surgery for Obesity and Related Diseases (SOARD) publishing results on risk-stratification of obesity class I & II by the fat z-scores in the American Society for Metabolic and Bariatric Surgery (ASMBS) guidelines/statements journal section of SOARD

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Two products powered this ascent: Mounjaro, approved for diabetes, contributed $22.97 billion, while Zepbound, indicated for obesity, delivered $13.54 billionwith the latter posting a staggering 175% annual growth rate

The challenge in triple-agonist design is balancing GCGR activity, because excessive glucagon signaling can offset incretin-mediated glycemic benefits