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More receptors does not automatically mean better, as the side effect profile and optimal dosing still need to be established
In a parallel matched cohort of 37,740 patients with both IBD and T2D, GLP-1 RA users had a 5-year colorectal cancer incidence of 0.31% vs 0.57% in non-users (OR, 0.54), representing a 46% reduction in odds

Stimulant laxatives such as bisacodyl (Dulcolax) and senna increase bowel contractions

Wegovy (Semaglutide) in Ireland About Wegovy Wegovy, the brand name for semaglutide when used for weight management, is now available in Ireland as an effective option for adults with obesity or those who are overweight with weightrelated health issues

Amelioration of neurodegeneration resulting from semaglutide treatment was also observed within the ventral posterior medial and lateral nuclei of the thalamus (VPM/VPL) of treated mice (Fig
These can lead to acid reflux
