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The discovery of statins While working at the Sankyo Company in 1976, the Japanese biochemist Akira Endo isolated a factor from the fungus Penicillium citrinum which he identified as a competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase)

Game changer

Approximately 100 cases were identified annually over six years, with the highest risk observed within the first year of medication use

Real-World Hypoglycemia Data from Clinical Trials In the SUSTAIN-6 trial (involving over 3,000 patients with type 2 diabetes), semaglutide used as monotherapy caused severe hypoglycemia in fewer than 1% of participants

doi: 10.1016/j.neuroscience.2015.06.054 Summary Keywords Parkinsons disease, diabetes, glucagon-like peptide 1, insulin, energy metabolism, neuroprotection Citation Lv D, Feng P, Guan X, Liu Z, Li D, Xue C, Bai B and Hlscher C (2024) Neuroprotective effects of GLP-1 class drugs in Parkinsons disease

A separate Phase 2a trial showed significant liver fat reduction in patients with MASLD/MASH