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These changes often lead to increased food intake and gradual weight regain

Protein intake is particularly important, with 1.01.2 grams per kilogram body weight daily recommended to preserve lean muscle mass

Glucose-dependent insulinotropic polypeptide is a growth factor for (INS-1) cells by pleiotropic signaling

And in the STEP trials, patient-reported physical functioning improved more on the drug than on placebo (STEP patient-reported outcomes, 2024), because unloading forty pounds of fat does more for how a body moves than a modest dip in muscle takes away

Understanding these mechanisms is essential for implementing appropriate protective strategies during GLP-1 treatment

These medications slow gastric emptying, which is how they promote fullness, but this also slows the entire digestive system