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Seek urgent medical attention for severe abdominal pain (possible pancreatitis), difficulty swallowing, vomiting blood, or persistent symptoms unresponsive to treatment

The hypothalamus, a part of the brain that controls satiety and appetite, is considered to express GLP-1 receptors, which are thought to play a role in weight loss

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[DOI] [PubMed] [Google Scholar] 58.Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, et al

Gastrointestinal disturbances occur less frequently with phentermine compared to GLP-1 receptor agonists, making it a consideration for GLP-1 agonist non-responders who experience intolerable digestive issues