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Conclusion GLP-1 RAs held therapeutic potential for KOA patients with obesity or diabetes, but current evidence remained insufficient, warranting further high-quality RCTs and mechanistic studies to confirm their efficacy and safety

Together, these medications provide robust HbA1c reduction with minimal hypoglycaemia risk, making them particularly valuable for patients requiring treatment intensification beyond metformin-based therapy

The results were remarkable

Dietary intake plays a pivotal role in triggering cytokine activation and subsequent inflammation

The targeting vector to create the models is based on a 10.5-kb genomic fragment from the murine Glp-1r ( mGlp-1r ) gene encompassing exons 1 to 2 and flanking sequences