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Semaglutide is a synthetic version of a naturally occurring hormone called GLP-1 (glucagon-like peptide-1), which plays an essential role in regulating appetite and food intake

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of prescription-only medications used primarily for managing type 2 diabetes and, more recently, for weight management

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These medications include semaglutide (marketed as Wegovy for weight management and Ozempic for diabetes) and liraglutide (Saxenda for weight management and Victoza for diabetes)

This means that such women lose the neuroprotective effect of estradiol