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In agreement with the finding that GLP-1Rknockout mice are protected from diet-induced obesity, one group showed that prolonged GLP-1R antagonism using a blocking antibody modestly attenuated weight gain in mice on a high-fat diet (94)

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Tirzepatide, a newer dual GLP-1/GIP receptor agonist, demonstrated even larger reductions in some studies, with systolic decreases reaching 68 mmHg in overweight patients

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Never stop prescribed medications without medical advice, but a comprehensive medication review may identify opportunities for optimisation that benefit both your primary condition and bowel health