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This 10%-point greater treatment effect (ie, treatment effect of 30% comparing GLP-1 RA exposure or no exposure vs 40% effect comparing GLP-1 RA and SGLT-2 inhibitor exposure) reflected that ferritin levels increased with SGLT-2 inhibitor exposure to the level of that seen for persons not exposed to either GLP-1 RAs or SGLT-2 inhibitors (figure 2A, maroon lines)

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doi: 10.1056/NEJMoa1411892 85 PizzimentiVGiandaliaACucinottaDRussoGTSmitsMCutroneoPMet al