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They can be minimized through gradual dose titration

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Maternal body mass index and pregnancy outcomes: a systematic review and metaanalysis

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However, no significant difference in eGFR was observed between tirzepatide and comparators

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doi: 10.1016/j.molmet.2022.101638 87 GasbjergLSHelstedMMHartmannBSparre-UlrichAHVeedfaldSStensenSet al

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The mechanism by which GLP-1 RAs potentially increase suicide or suicide attempts is unclear but may involve an overactivation of the hypothalamic-pituitary-adrenal (HPA) axis [7], rapid weight loss [8], and reduced expression of brain-derived neurotrophic factor which may link weight changes to heightened anxiety and suicidal risk [9]

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Liraglutide for adolescents with obesity

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