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Of the 164 trials, 34% (N = 56) assess disease-modifying biological agents, 41% (N = 68) test disease-modifying small molecule drugs, 10% (N = 17) evaluate cognitive enhancing agents, and 14% (N = 23) test drugs for the treatment of neuropsychiatric symptoms
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PARylation Upon sensing DNA damage (e.g., single-strand breaks), PARPase (especially PARP1) is activated and rapidly accumulates at the site of damage
It originates in the lower spine and travels through the glutes and down the back of the leg
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