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Tirzepatide (Zepbound/Mounjaro): A dual GLP-1/GIP receptor agonist undergoing evaluation for MASH after demonstrating significant liver fat reduction in studies.Retatrutide: A "triple agonist" targeting GLP-1, GIP, and glucagon (GCGR) receptors, which has shown "unprecedented" efficacy in weight loss and is being evaluated for metabolic diseases including MASH

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Verified April 2026.

A recent composition for the Obesity Medicine Association titled "A New Path Forward" highlights struggles people living with obesity face, and has been viewed over 4,000 times

Semaglutide vs tirzepatide: how they work, expected weight loss, side effects, and cost a head-to-head from Texas-licensed family physicians.
doi: 10.7759/cureus.53810
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