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Elevated adiponectin concentrations have been noted in major clinical trials with GLP-1RAs (188) and, more robustly, with tirzepatide (189)

Tirzepatide: Unlike a semaglutide, this peptide is a dual agonist

[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Rai P., Madi M.Y., Dickstein A

GLP-1 RAs have also been suggested to be nephroprotective [10], even though conflicting data on renal sodium and water handling have been reported [1012]

Our findings expand proteinprotein modulation drug discovery to uncompetitive, active state stabilizers for peptide hormone receptors
