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Pharmacoepidemiol Drug Saf 2015;24:10091016 [DOI] [PubMed] [Google Scholar]

[DOI] [PMC free article] [PubMed] [Google Scholar] 218.Maniscalco J.W., Rinaman L

[DOI] [PMC free article] [PubMed] [Google Scholar] [19].Lewis AL, Richard J, Challenges in the delivery of peptide drugs: an industry perspective, Therapeutic Delivery 6(2) (2015) 149163

The pooled GLP1-RA analysis demonstrated benefits in the secondary endpoints as well, with a 13% reduction in cardiovascular death [HR, 0.87 (0.800.94)], 10% reduction in MI [HR, 0.90 (0.830.98)], 17% reduction in stroke [HR, 0.83 (0.760.92)], 11% reduction in heart failure hospitalizations [HR, 0.89 (0.820.98)], and 12% reduction in all-cause mortality [HR, 0.88 (0.820.94)] [26]

Most human trials to date have been short-term or involved patients who already had significant brain damage

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