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The authors conclude: In the STEP TEENS trial, treatment with semaglutide 2.4 mg once weekly for 68 weeks was associated with a significant reduction of levels of the liver enzyme alanine aminotransferase compared with placebo. Dr Weghuber adds: Fatty liver disease is the most frequent liver disease in adolescents with no drug therapy currently available

Overall Assessment: Weighing the Pros and Cons Dr

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Clinical studies have shown that patients using GLP-1 medications under medical supervision achieve significantly greater weight loss outcomes than those using lifestyle modifications alone

Each receptor contributes a different lever, and the clinical question Phase 3 needed to answer was whether those levers stack in humans the way they do in preclinical models

Mechanism of action Retatrutide activates the GIP, GLP-1, and GCG receptors simultaneously, which may lead to better weight loss and cardiometabolic benefits compared to targeting a single receptor