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Order one vial, test it, then scale up if it passes

That includes proactive management of side effects, candid conversations about the long-term nature of treatment, infrastructure to identify and support patients at risk of stopping and addressing the cost barriers that make GLP-1 therapy unsustainable for many. These measures are especially important, Al-Aly noted, because the cardiovascular protection provided by GLP-1 medication builds slowly, but it erodes quickly

10.1161/CIRCULATIONAHA.106.675355 26 GersteinH

Step 3 - Medication Support Options For Persistent Nausea For some people, nausea may persist despite lifestyle changes and slow titration

Circulation 142 (11), 10281039

9 In a 72-week study of tirzepatide specifically for weight loss in nondiabetic patients who were overweight or obese, findings were especially dramatic ( Figure 2A and Figure 2B )