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Barriers to Injectable GLP-1 RA Therapy Quite a few barriers have been identified related to injectable GLP-1 RA therapy

doi: 10.1677/jme.0.0100259 44 GallwitzBWittMPaetzoldGMorys-WortmannCZimmermannBEckartKet al

Clinical trials have shown that orforglipron results in just over 15% body weight loss in adults with obesity, placing it on par with that seen with Wegovy, but significantly lower than the 21% weight loss seen with Mounjaro

Marx et al

References: Pharmacokinetics and Tolerability of a Single Dose of Semaglutide, a Human Glucagon-Like Peptide-1 Analog, in Subjects With and Without Renal Impairment Semaglutide s.c

It belongs to a class of drugs known as sympathomimetic amines, meaning it mimics adrenaline-like signals in the body