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Some patients achieve their weight loss goals at intermediate doses and never require escalation to 15mg
Adaptation pathways (brainstem nausea circuit, sinus-node baroreflex) respond to rate of change in receptor occupancy
Yes, semaglutide is not recommended during breastfeeding due to limited safety data, but you can restart it after weaning
doi:10.1016/j.neuropharm.2013.08.005 142
