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Additionally, selective deletion of Gipr in brown adipose tissue significantly increases both fasting (overnight) and fed (1h re-feed) TG levels of high-fat fed mice ( Gipr BAT / mice fed a high-fat diet for 810 weeks housed at room temperature reveal significantly increased TG excursion, an effect lost upon 28 weeks of high-fat feeding (Kim et al., 2007a) mediated by resistin (Kim et al., 2007b) and in human adipocytes by increasing TORC2 and phospho-CREB nuclear localization to bind to the CRE-II promoter region (Kim et al., 2010)

What Is GLP-1, and How Does It Work

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doi: 10.1002/dmrr.3070 Summary Keywords GLP-1 receptor agonists, thyroid disorders, thyroid cancer, meta-analysis, randomized controlled trials Citation Hu W, Song R, Cheng R, Liu C, Guo R, Tang W, Zhang J, Zhao Q, Li X and Liu J (2022) Use of GLP-1 Receptor Agonists and Occurrence of Thyroid Disorders: a Meta-Analysis of Randomized Controlled Trials

Of those, 4 RCTs [1, 2, 4] as SURMONT-OSA Trial by Malhotra et al