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Patients on tirzepatide lost an average of 1.1 percent more lean body mass after three months and 2 percent more after 12 months of continuous use than those on semaglutide, based on an analysis by Massachusetts-based data analytics firm nference

"Obesity Drugs: The Next Wave of GLP-1 Competition." September 2024

This helps prevent hypoglycemia during fasting and allows the body to tap into energy reserves when food is not available

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