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Data Availability Statement The data supporting the findings of this study are available on the websites mentioned in the References section.

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In health, GLP-1 stimulates the synthesis and secretion of insulin from pancreatic -cells in a glucose-dependent manner (i.e., it is activated when blood glucose levels are elevated, typically in the postprandial state)

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Cold stress in female GLPDRKO mice does not significantly impact body weight gain or lipid tolerance but does significantly shorten intestinal transit time In female mice, plasma leptin levels were significantly lower with cold stress independent of genotype (Fig