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doi: 10.1038/s41467-021-23376-6 189 MaleckiM
c , Heterologous competition binding of exendin-4 and exendin-3 at the wild-type GLP-1R determined using 3 H-peptide 1

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Similar to our primary analysis, we calculated 3 different comorbidity scores: the VHA frailty index 60 , the weighted CCI 61,62 ,and cardiovascular risk as calculated by DAgostino method 63

Despite the significant burden of disease, effective pharmacological options remain limited, leaving lifestyle interventions based on dietary modification and physical activity as the mainstay of clinical management [6]
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