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Intermediate endpoints showed similar differences as in the primary analysis (ESM Table 2)

We employed a new user, active comparator design

Notably, patients with MASH or cirrhosis showed greater relative benefit from combination therapy compared to those without these conditions, suggesting that patients with more advanced liver disease might be prime candidates for this therapeutic approach

Any opinions and estimates constitute our judgment as of the date of this material and are subject to change without notice

The company has indicated it is running additional trials in obesity-related conditions such as heart disease and chronic kidney disease, with further results expected to begin emerging next year
