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P5 is a weak insulin secretagogue and improves glucose tolerance As P5 clearly demonstrated ligand bias in vitro with respect to Ex4, the challenge was to determine how the in vitro bias activity of P5 translates to in vivo efficacy

Cardiovascular side effects with semaglutide are generally mild, and the SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events (MACE) in people with established heart disease

The next generation of treatments GLP-1 receptor agonists have transformed the management of type 2 diabetes and obesity, but their therapeutic potential extends far beyond glucose regulation

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We havent really had a new tool in our toolbox from a pharmacotherapy perspective to treat addiction in a long time, said Lembke, noting that some addiction specialists are already prescribing GLP-1s off-label, especially when other treatments have failed
