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Increasing evidence has demonstrated that GLP-1 analogues can cross the blood-brain barrier, protect dopaminergic neurons in the substantia nigra, and rescue motor activity and cognitive functions in PD animal models (5961)

5 Likewise, research published in 2024 indicates that semaglutide approximately doubles NAION risk, albeit with a very low absolute incidence, emphasizing the need for clinicians and patients to remain vigilant

Evidence-Based Treatments for Fibromyalgia in the UK The cornerstone of fibromyalgia management in the UK follows NICE Guideline NG193 on chronic pain, which recommends a holistic, patient-centred approach

GLP-1 refers to a class of medications which mimic a hormone called glucagon-like peptide 1

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Some patients say semaglutide made them feel more anxious or depressed A review of real-world data from healthcare databases and registries is underway