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Even though it is less consumed, guarana (Paullinia cupana), native to the Amazon rainforest, contains one of the highest natural concentrations of caffeine (2.5% to 8.0% in dry weight) with a chemical profile also rich in phenolic compounds like theobromine, catechins and tannins.2 The tannins help to slow the release of caffeine into the bloodstream, resulting in a more prolonged stimulatory effect.3 This unique pharmacokinetic behavior has led to the widespread incorporation of guarana extract into energy drinks and fatigue-reducing supplements
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Yerba mate may curb appetite and aid weight loss, but is it really comparable to Wegovy, like social media suggests

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Stunkard Professor and former Director of the Center for Weight and Eating Disorders at the University of Pennsylvania School of Medicine
The number on the scale may be acting like the 'canary in the coal mine.' It may be telling us about swallowing issues, loss of smell, gastrointestinal dysfunction, frailty, muscle loss, medication interactions or changes in cognition long before these problems become obvious
