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High risk and low prevalence diseases: metformin toxicities

These reports describe reduced limb circumference, decreased heaviness, and improved mobility

doi: 10.1016/j.yfrne.2009.10.008
This can increase sodium and water excretion and may slightly reduce circulating blood volume

Prevention or delay of type 2 diabetes and associated comorbidities: standards of care in diabetes-2023
Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials
