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RESULTS 3.1 Tirzepatide reduces body weight and improves glucose tolerance in HFD-fed mice Mice were subjected to high-fat diet (HFD) feeding with 12 weeks and followed with different drugs administration for 2 weeks, including vehicle, 10 nM [D-Ala2]-GIP, 10 nM semaglutide, 3 nM tirzepatide, and10 nM tirzepatide (Fig.1A)

In early August, Novo Nordisk announced that Wegovy reduces the risk of heart attack, stroke or heart-related death in people with cardiovascular disease and obesity by 20%, a result expected to boost use of the medicine even further

Side Effects and Safety Profiles Because both forms contain semaglutide, their side-effect profiles are largely similar, such as: Nausea Vomiting Diarrhea Constipation These effects are typically dose-related and most noticeable during early treatment or dose increases

At 20mg/mL concentration: 2.5mg equals 12.5 units

Women and Caucasians were noted to have the highest prevalence of gastroparesis, and multiple studies support the female predominance of gastroparesis with as high as 80% of cases affecting female individuals [5,7,8]