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Description
In order to make GLP-1 better used in the clinic, drug developers modified its structure and developed a series of GLP-1R agonists ( GLP-1, a 30- or 31-amino-acid-long peptide hormone, is a gastrointestinal peptide secreted by the intestinal tract that potentiates insulin release and reduces glucagons concentration in physiological conditions ( Scheme 1
GLP-1 therapy also doesn't have to stand alone
Treated mice exhibited reduced food intake, attenuated weight gain, and improved glucose metabolism and insulin sensitivity without detectable adverse effects
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Gut 66 , 10311038 (2017)
