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Una reciente revisin narrativa analiza los efectos del agonismo del receptor de incretina particularmente de los agonistas del receptor del pptido similar al glucagn tipo 1 (GLP-1RA) y de los agonistas duales de los receptores GLP-1 y GIP (GLP-1/GIPRA) sobre la masa libre de grasa (MLG) y la aptitud cardiorrespiratoria

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Pre-treatment with a GLP1 receptor-blocking antibody neutralised the CNO-dependent improvement in glucose tolerance but did not affect the reduction in food intake, and an independent group of animals pair-fed to the CNO-treatment group demonstrated attenuated weight loss

Experimental studies using GLP-RT have explored how tri-receptor activation influences metabolic signaling across tissues in preclinical systems