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Risk Factors History of stomach issues or motion sickness Rapid dose increases Starting at higher doses Large, high-fat meals Eating too quickly Dehydration Existing metabolic disorders or obesity Female gender (noted in some studies) Metabolic disorders such as obesity exacerbate nausea

Notably, treatments with the multi-agonists or GLP1 did not cause signs of nausea/malaise at any time-point tested (272 h), since pica behavior (i.e., kaolin intake) was similar, or even lower, in mice treated with GLP1/E, GLP1/GIP, GLP1/GIP/Glucagon, or GLP1 vs

However, because incretin agonists are relatively new to the market for obesity, the impacts on cancer are just beginning to be understood

The Multicenter Study Group

Gradual dose escalation has proven to minimize adverse events effectively
