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M., Jain, R., Ahren, B., Pacini, G

The neuroprotection effect of GLP-1 was further displayed in studies in which treatment with liraglutide, lixisenatide, or geniposide in the transgenic amyloid precursor peptide/presenilin 1 mice produced improvements in synaptic plasticity and reduced neuronal damage, tau hyperphosphorylation, microglial activation, plaque, and oligomer formation in the CNS (Perry et al., 2002

Together, these observations point to a mismatch between circulating GLP-1 levels and GLP-1 function

doi: 10.1056/NEJMoa1911303
