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doi:10.1186/s40814-022-00990-9 DISCLAIMER: These statements have not been approved by the Food and Drug Administration

Among the observational studies 39,45,46,49,50,51 comprised by the meta-analyses, two are worth a separate mention

[DOI] [PubMed] [Google Scholar] 73.Johnson KC, Bray GA, Cheskin LJ, Clark JM, Egan CM, Foreyt JP, et al

Mentlein, R

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Lyall V, Alam RI, Phan DQ, Ereso GL, Phan TH, Malik SA, Montrose MH, Chu S, Heck GL, Feldman GM, DeSimone JA

For example: People put on GLP-1 drugs might differ in meaningful ways from those started on SGLT-2s or DPP-4s Severity of diabetes, weight, blood pressure patterns, sleep apnea, smoking history, and other factors can be hard to capture perfectly in claims Diagnostic coding can be imperfect Follow up time was up to 18 months, not years That said, the study is large, and it tries to do the comparison thoughtfully