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This rate often accelerates after age 60 and leads to sarcopenia and an increased risk of reduced mobility, frailty, osteoporosis, and cardiovascular disease

This multi-pathway approach is what sets retatrutide apart from more familiar medications that focus on only one hormone system

they're a proactive strategy for improving overall metabolic function, often playing a role in reversing or managing metabolic syndrome
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They occur in about three-quarters of people on either semaglutide or tirzepatide
This combination is likely to increase the risk of side effects
Additionally, semaglutide is FDA-approved for weight management to reduce the risk of cardiovascular death, myocardial infarction, and stroke in adults with obesity or overweight individuals with heart disease, and is available in a maximum dose of 2.4 mg per injection
