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Tirzepatide has a dual-receptor action, targeting both GLP-1 and GIP, which leads to more significant weight loss compared to Semaglutide, which only targets GLP-1

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Accumulating evidence suggests that semaglutide modulates adipocyte lipid handling through both central and peripheral mechanisms, thereby influencing lipolysis, fatty acid flux, and adipose tissue metabolic flexibility [35]

The most common side effects are GI-related and tend to be most noticeable when you're starting out or stepping up in dose which is exactly why we titrate slowly

Effects of berberine on expression of LOX-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL

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