retatrutide and semaglutide together vs Semaglutide: Key Differences Explained What Are the Mechanism Differences

1098-1111, Moon, Ki Hak, et al

#RevolutionMed #EvidenceBasedMedicine #FunctionalMedicine #washingtondc #Norfolk #NYC #Health #Obesity #WeightLoss #Zepbound #Semaglutide #Ozempic #Wegovy #Charlottesville #cville #uva #epitomee To view or add a comment, sign in Good morning

As retatrutide has not yet received marketing authorisation from the MHRA or EMA, it is only available within regulated clinical trials in the UK

It should also be avoided in patients with coexisting uncontrolled liver diseases (eg, autoimmune hepatitis), uncontrolled hypothyroidism or hyperthyroidism, symptomatic gallstone-related diseases, and ongoing alcohol consumption of 20 g or more per day for women or 30 g or more per day for men

These may indicate underlying conditions requiring specific workup

GIPR: Similar Receptors, Distinct Signaling Properties Many of the aforementioned studies that provide substantial evidence for the G s protein bias of GLP-1R signaling studied the same signaling properties of the closely related GIPR in parallel and reported interesting and striking distinctions between these two glucagon family receptors