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While early studies have noted sex differences in the response to these drugs, the nature of these differences remain poorly characterized

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They operate through distinct neurological and metabolic pathways

Glucagon-like peptide 1 (GLP-1) is a cleavage product of the pre-proglucagon gene which is expressed in the -cells of the pancreas, the L-cells of the intestine, and neurons located in the caudal brainstem and hypothalamus

Clinical trials of FDA-approved tirzepatide products have shown weight-related effects in some participants when used alongside diet and lifestyle changes