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Why menopause makes weight loss harder Declining estrogen changes where and how your body stores fat

GLP-1 RA microdosing uses doses below the smallest available commercial threshold typically starting at 0.1250.25 mg semaglutide weekly and often extends dosing intervals to every 10, 14, 21, or 28 days

These drugs help patients achieve sustainable weight loss, improve insulin sensitivity, and lower the risk of heart disease

We hope these findings can be helpful for clinicians to better apply them in practice

National Science & Technology Major Project of ChinaKey New Drug Creation and Manufacturing Program 2018ZX09735001 (MWW) and 2018ZX09711002002005 (DHY)
In clinical trials, serious adverse effects requiring discontinuation were reported in less than 2% (9,28,29)
