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Indications Hypertension first-line or add-on therapy Diabetic nephropathy especially in type 2 diabetes with proteinuria Heart failure for patients intolerant of ACE inhibitors Post-myocardial infarction reduces morbidity and mortality 3

A prospective meta-analysis supports the cardiovascular safety of the dual incretin receptor agonist tirzepatide, after promising clinical outcomes in the SURPASS-4 study.

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