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Weight loss averages 3-5% of body weight

3 Department of Endocrinology and Diabetes, 424 General Military Hospital, Thessaloniki, Greece

People on tirzepatide lost about 50 pounds originally and gained an average ten pounds back after switching to orforglipron

However, in the subgroup of patients with insulin resistance, severe obesity and higher odds ratio for the metabolic syndrome, BMI decreased more with liraglutide than with metformin (2.13 kg/m 2 vs

Ultimately, the choice depends on your treatment goals, tolerance, insurance coverage, and whether your priority is weight loss, cardiovascular health, or metabolic control

Importantly, lean tissue has a higher metabolic rate than adipose tissue, and its preservation is critical for sustaining metabolic health, physical function, and long-term weight maintenance