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Better together A new combination therapy shows promise for Type 2 diabetes By Claire Kowalick Just as there are many causes of Type 2 diabetes, its treatment may also require a multi-layered approach

doi: 10.1038/s41366-024-01500-y 166 TrappSBrierleyDI

Anti-inflammatory mechanism at low doses The anti-inflammatory effects of GLP-1R agonism are not dose-dependent in the same way that weight loss is

DPP-4 inhibition augments the levels of GLP-1 and GIP, reduces blood sugar levels, and boosts insulin production

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Conclusions An anti-obesity treatment framework focused on both phenotype and complication burden improves the personalization of obesity care and supports clinical decision-making throughout a persons lifespan