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Because patients who discontinued WEGOVY injection during titration and those who did not reach the 2.4 mg weekly dose were not eligible for the randomized-treatment period, the results may not reflect the experience of patients in the general population who are first starting WEGOVY injection

GLP-1 Pathway and Appetite Regulation Semaglutide works by activating the glucagon-like peptide-1 (GLP-1) receptor in the body

Helps compare the economic reality of different dose levels and different medications

References Dosing Schedule | Ozempic (semaglutide) injection 0.5 mg or 1 mg

Blunts appetite signals in the brains hypothalamus

Cells were lysed with RIPA buffer (Astral Scientific, Sydney, Australia) and total DNA quantified using Quanti-iT PicoGreen (Life Technologies, Gaithersburg, MD, USA)