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Evaluate real-world clinical use, including disease impact, safety profiles, and contraindications, as well as further uses of these medicines as co- and poly-agonists in applications beyond diabetes and obesity

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Regardless of any judgments people have on the utility and value of these drugs, they are here to stay

For example, once weekly dosing of tirzepatide (a dual GIPR and GLP-1R co-agonist) has superior efficacy for weight reduction compared to the GLP-1R agonist, semaglutide

As with any medication, there are risks associated with using GLP-1s, and much of that risk depends on an individuals health history

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