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GLP-1 signaling has been shown to inhibit activation of the NLRP3 inflammasome, a key driver of innate immune-mediated inflammation, and to enhance Treg activity, suggesting a broader role in restoring immune tolerance [26,27]

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15 Additionally, the 2019 guidelines issued by the European Society of Cardiology and the EASD suggest using GLP1 RA as initial therapy in patients with type 2 diabetes and cardiovascular disease or those at high risk of cardiovascular disease (no class recommendation)

Metformin has been a cornerstone of type 2 diabetes treatment for over five decades, recommended by the American Diabetes Association as a first-line treatment alongside lifestyle changes