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[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Buckley ST, Bkdal TA, Vegge A, et al

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Structured physical activity enhances vascular and metabolic health, increases neurotrophic signaling, strengthens synaptic plasticity, and bolsters mitochondrial resilience, with benefits documented across aging, AD, and PD populations (228230)

Beyond absolute oxidative rate, mitochondrial resilience depends on spare respiratory capacitythe difference between basal and maximal electron transport fluxwhich reflects the ability to accommodate additional energetic demand without redox disequilibrium [64, 65]

These drugs can curb both appetite and thirst, leading to low fluid intake, fatigue, dizziness, and digestive slowdown