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Incretins, however, are rapidly degraded by dipeptidyl peptidase-4 resulting in fleeting half-lives of 12 min (Fig

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10.1038/s41582-024-00988-2 60 JastreboffA

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Abbreviations used in this paper: ALI acute lung injury BALF bronchoalveolar lavage fluid cAMP cyclic adenosine monophosphate COPD chronic obstructive pulmonary disease FDA US Food and Drug Administration FEV1 forced expiratory volume in one second FVC forced vital capacity GLP-1 glucagon-like peptide-1 GLP-1R glucagon-like peptide-1 receptor ILC2 group 2 innate lymphoid cells IL interleukin LPS lipopolysaccharide NO nitric oxide OVA ovalbumin PKA protein kinase A RSV respiratory syncytial virus T2D type 2 diabetes mellitus Th2 T-helper type 2 TSLP thymic stromal lymphopoietin Footnotes Declaration of Interest: The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed Reviewer Disclosures: Peer reviewers on this manuscript have no relevant financial or other relationships to disclose

For any pre-meal protein preload, randomized trials show modest reductions in post-meal calorie intake (515%) and better post-meal glucose control